TY  - ADVS
AU  - Maquat,Lynne E.
TI  - Nonsense-mediated and Staufen1-mediated mRNA decay: related pathways of post-transcriptional control in mammalian cells 
T2  - From DNA to proteins : the multiple levels of regulation,
PY  - 2007///
CY  - London
PB  - Henry Stewart Talks
KW  - Cellular control mechanisms
KW  - Genetic regulation
KW  - Messenger RNA
KW  - RNA stability
KW  - Cytoskeletal Proteins
KW  - physiology
KW  - Eukaryotic Initiation Factors
KW  - metabolism
KW  - Exons
KW  - Nonsense Mediated mRNA Decay
KW  - Protein Isoforms
KW  - RNA Cap-Binding Proteins
KW  - RNA Processing, Post-Transcriptional
KW  - RNA Splicing
KW  - RNA Stability
KW  - RNA, Double-Stranded
KW  - RNA, Messenger
KW  - RNA-Binding Proteins
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Three core Upf NMD factors -- Exon junction complexes (EJCs) -- Upf1 -- Mechanism of NMD -- Activation of EJC-bound Upf1 -- Role of NMD in downregulating spliced mRNAs to eliminate truncated proteins -- NMD downregulating functional protein isoforms -- Restriction to newly synthesized mRNAs during a pioneer round of translation -- Cap Binding Protein (CBP) heterodimer CBP80-CBP20 -- Eukaryotic translation initiation factor (eIF) 4E and steady state mRNA -- Role of CBP80 in enhancing efficiency of NMD by promoting the interaction of Upf1 with EJC-bound Upf2 -- Staufen (Stau)1-mediated mRNA decay (SMD) -- Double-stranded RNA binding protein Stau1 -- Mechanism of action of SMD; Access restricted to subscribers
UR  - https://hstalks.com/bs/629/
UR  - https://hstalks.com/bs/p/22/
ER  -