TY - ADVS AU - Rodnina,Marina V. TI - Elongation of protein synthesis: structural basis of the peptide bond T2 - From DNA to proteins : the multiple levels of regulation, PY - 2007/// CY - London PB - Henry Stewart Talks KW - DNA KW - Gene Expression Regulation KW - Proteins KW - Transcription Factors N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: The ribosome -- Chemistry of peptide bond formation -- Structure of the peptidyl transferase center of the ribosome -- Structures of the catalytic subunit with reaction substrates and transition state analogs -- Induced fit in peptide bond formation and peptidyl-tRNA hydrolysis -- Reaction pathways of catalyzed and uncatalyzed reactions -- pH dependence of catalysis -- Entropic catalysis -- Role of active site residues -- Importance of 2' OH of A76 of the tRNA in the P site -- The mechanism of peptide bond formation; Access restricted to subscribers UR - https://hstalks.com/bs/635/ UR - https://hstalks.com/bs/p/22/ ER -