TY - ADVS AU - Westaway,David TI - Experimental therapies in Alzheimer's disease: the development and use of mouse models T2 - Neurodegenerative diseases : fundamentals, research methods, latest advances, PY - 2007/// CY - London PB - Henry Stewart Talks KW - Alzheimer Disease KW - Disease Models, Animal KW - Neurodegenerative Diseases N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Animal models and AD research -- Role in identifying pathological pathways, biomarkers and candidate therapies -- Design of models and associated technical parameters -- Process of transgenesis -- Developing mouse models for beta-amyloid precursor protein mutations -- TgCRND8 mice -- Transgenic approaches for investigating Tau mutations -- Exploring environmental modifiers of beta-amyloid pathobiology -- Candidate chemical risk-factor for sporadic AD -- Potential of ''smart'' beta-amyloid-directed interventions; Access restricted to subscribers UR - https://hstalks.com/bs/234/ UR - https://hstalks.com/bs/p/31/ ER -