TY - ADVS AU - Mayer,R.J. TI - Ubiquitination and Alzheimer related disorders: new insights and possible therapeutic approaches! T2 - Neurodegenerative diseases : fundamentals, research methods, latest advances, PY - 2007/// CY - London PB - Henry Stewart Talks KW - Alzheimer Disease KW - Neurodegenerative Diseases KW - Ubiquitin KW - therapeutic use KW - Ubiquitination N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Alzheimer's disease and dementia with Lewy bodies -- Ubiquitin and the ubiquitin pathway of intracellular proteolysis -- Ubiquitin immunocytochemistry in understanding chronic neurodegenerative disease -- Ubiquitin and the discovery of dementia with Lewy bodies -- Importance of ubiquitin for normal brain functions -- Ubiquitin and Parkinson's disease -- Intraneuronal protein aggregation and neurodegenerative disease -- Experimental demonstration of generic gene expression changes in response to protein aggregates -- Expression of the mitogen activated protein kinase (MEK5) -- ERK5 kinase module in Alzheimer's disease and dementia with Lewy bodies -- Ubiquitin-p62-MEK5/ERK5 pathway of neuronal survival in Alzheimer related disorders -- Diagnostic and therapeutic importance of ubiquitin/kinase mediated neuronal survival and anti-apoptotic pathways; Access restricted to subscribers UR - https://hstalks.com/bs/228/ UR - https://hstalks.com/bs/p/31/ ER -