TY  - ADVS
AU  - Sarazan,R.Dusty
TI  - Safety pharmacology in human pharmaceutical development
T2  - Non-clinical testing for toxicity of pharmaceuticals : regulatory and practical standards for testing and application,
PY  - 2009///
CY  - London
PB  - Henry Stewart Talks
KW  - Drug Toxicity
KW  - Toxicity Tests
N1  - Animated audio-visual presentation with synchonized narration; Title from title frames; Contents: Adverse functional effects of drugs on vital organ systems have resulted in patient deaths and several product withdrawals over the past two decades -- The potential for these effects was not detected in the traditional toxicology studies that were conducted at the time -- These unfortunate events have led to the introduction of new international regulatory guidelines and the creation of a new discipline, known as safety pharmacology, which is distinct from toxicology -- Safety pharmacology involves experts in pharmacology who specialize in acute adverse effects of potential human drugs, primarily on the cardiovascular, respiratory and central nervous system -- These three organ systems have been deemed to be the ones that are acutely critical for life -- If safety pharmacology studies had been conducted in the past, according to today's standards, the vast majority of the drugs that resulted in human deaths would never have made it; Access restricted to subscribers
UR  - https://hstalks.com/bs/1341/
UR  - https://hstalks.com/bs/p/438/
ER  -