TY - ADVS AU - Navarro,Victor J. TI - Drug induced liver injury: a clinical perspective T2 - Non-clinical testing for toxicity of pharmaceuticals : regulatory and practical standards for testing and application, PY - 2009/// CY - London PB - Henry Stewart Talks KW - Drug Toxicity KW - Toxicity Tests N1 - Animated audio-visual presentation with synchonized narration; Title from title frames; Contents: Definition of drug induced liver injury (DILI) -- Types and mechanisms of DILI -- Safety withdrawals -- Signals of DILI in drug development -- Epidemiology of DILI -- Clinical patterns -- Hepatocellular liver injury -- Cholestatic liver injury -- What comprises liver injury? -- Adaptation to injury -- Toxicity grading in clinical trials -- Jaundice -- Common signatures of DILI -- Susceptibility factors for DILI -- Key elements in diagnosis -- Causality assessment tools -- Management of DILI -- Monitoring in clinical practice; Access restricted to subscribers UR - https://hstalks.com/bs/1346/ UR - https://hstalks.com/bs/p/438/ ER -