TY - ADVS AU - Weinberg,Robert A. TI - Invasion, metastasis and stem cells T2 - The biomedical & life sciences collection, PY - 2009/// CY - London PB - Henry Stewart Talks KW - Neoplasm Metastasis KW - physiopathology KW - Neoplastic Stem Cells N1 - Animated audio-visual presentation with synchonized narration; Title from title frames; Contents: Vogelstein-Kinzler model of multi-step colon cancer pathogenesis -- Cell of origin determines tumor morphology and behaviour -- Hierarchical organization of normal epithelial tissues -- Similar hierarchical organization of cancer cells in a tumor -- The invasion-metastasis cascade -- Physical dissemination -- Adaptation to and proliferation in a foreign tissue -- Colonization -- Epithelial-mesenchymal transition (EMT) -- The microenvironment of the primary tumor -- Twist transcription factor -- Slug TF -- What is the nature of cells generated by an EMT? -- EMT and cancer progression; Access restricted to subscribers UR - https://hstalks.com/bs/1376/ ER -