TY - ADVS AU - Raulet,David H. TI - Education of NK cells: disarming of autoreactive NK cells T2 - Natural killer cell biology : natural killer cell-mediated immunity to pathogens and cancer, PY - 2009/// CY - London PB - Henry Stewart Talks KW - Cytotoxicity, Immunologic KW - Killer Cells, Natural KW - Neoplasms N1 - Animated audio-visual presentation with synchonized narration; Title from title frames; Contents: NK cell "education" -- NK cells in normal animals attack cells that lack some or all self MHC class I molecules -- NK cells that lack inhibitory receptors for self MHC class I are rendered hyporesponsive and self tolerant -- Hyporesponsiveness of NK cells is induced by target cells lacking MHC I, as in a mixed chimera -- Responsiveness of NK cells varies depending on how many MHC I-specific receptors they express -- NK cell education ensures that NK cells are optimally responsive yet not autoreactive; Access restricted to subscribers UR - https://hstalks.com/bs/1451/ UR - https://hstalks.com/bs/p/440/ ER -