TY  - ADVS
AU  - Cantley,Lewis
TI  - Role of the PI 3-kinase signaling pathway in cell regulation and human disease
T2  - Protein phosphorylation,
PY  - 2010///
CY  - London
PB  - Henry Stewart Talks
KW  - Phosphatidylinositol 3-Kinases
KW  - Signal Transduction
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Phosphoinositide 3-kinase (PI3K) signaling -- Class Ia PI3K's and the mediation of growth factor signaling -- The receptor tyrosine kinase signaling pathway -- Loss-of-function mutations in tumor suppressors -- Sporadic mutations -- Drug targets -- Regulation of metabolism by PI3K AKT signaling -- Targets of the drug NVP BEZ235 -- Generation of mice with mutant PI3K p110a -- How lung adenocarcinoma requires mutant PI3K -- HIF-1alpha -- Visualizing lung tumors using FDG PET -- How mTOR inhibition does not reduce tumor volume -- Will a PI3K inhibitor kill K-Ras driven tumors? -- How AKT inhibition does not affect tumor size or activity -- Effects of BEZ235 in K-Ras mutant tumors -- How BEZ235 specifically kills PI3K driven tumors -- The drug ARRY 886 -- How PI3K with MEK inhibitors eradicates K-Ras tumors -- Blocking the PI3K and MAP Kinase pathways -- Inhibition of S6 kinase in K-Ras tumors; Access restricted to subscribers
UR  - https://hstalks.com/bs/1880/
UR  - https://hstalks.com/bs/p/531/
ER  -