TY - ADVS AU - Pawson,T. TI - Modular protein-protein interactions provide a general mechanism to organize dynamic cellular systems T2 - Protein phosphorylation, PY - 2010/// CY - London PB - Henry Stewart Talks KW - Cellular signal transduction KW - Phosphorylation KW - Proteins KW - Receptor Protein-Tyrosine Kinases KW - Signal Transduction N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Updated version of a talk first published 2007; Contents: Mechanisms through which protein interactions modules, such as the SH2 domain, mediate the activation of specific signaling pathways by normal and oncogenic tyrosine kinases -- The biological functions and biochemical properties of interaction domains including their roles in controlling protein localization, in recognition of post-translational modifications, in forming multi-protein complexes, and in regulating enzymatic function -- The versatility of interaction domains, their potential utility in the evolution of new signaling pathways, and their exploitation by pathogenic proteins to rewire cellular behavior; Access restricted to subscribers UR - https://hstalks.com/bs/1881/ UR - https://hstalks.com/bs/p/38/ UR - https://hstalks.com/bs/p/531/ ER -