TY - ADVS AU - Field,Hugh J. TI - Herpes simplex virus and varicella-zoster virus Helicase-Primase inhibitors T2 - Antivirals : latest developments and future progress, PY - 2011/// CY - London PB - Henry Stewart Talks KW - Antiviral agents. KW - Herpes simplex virus KW - Effect of drugs on. KW - Herpesvirus diseases. KW - Antiviral Agents KW - pharmacology. KW - DNA Helicases KW - antagonists & inhibitors. KW - DNA Primase KW - Herpes Simplex KW - drug effects KW - Herpesvirus 3, Human N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Herpesvirus infections in man -- Diseases caused by alphaherpesvirus, HSV and VZV -- Immunocompromised hosts -- Infection, latency and reactivation -- Morphology of herpesvirus virion -- Productive replication cycle -- The herpesvirus genome -- HSV and VZV antiviral therapy -- Nucleoside analogue therapy -- Historical prospective -- Genes coding for proteins targeted by antivirals -- Inhibitors of DNA synthesis -- A new target -- HSV helicase-primase complex -- Clinical potential of Helicase primase inhibitors (HPIs) -- Studying HPI in vivo -- Antiviral efficacy -- Dose response -- The effects of HPI on HSV latency -- The development of HPI antiviral drug resistance -- HPI resistant mutants growth and pathogenicity; Access restricted to subscribers UR - https://hstalks.com/bs/2074/ UR - https://hstalks.com/bs/p/613/ ER -