TY - ADVS AU - Rusakov,Dmitri A. TI - Regulation of synaptic plasticity by astroglia T2 - Physiology and pathophysiology of neuroglia : roles in health and disease, PY - 2012/// CY - London PB - Henry Stewart Talks KW - Astrocytes KW - Cellular signal transduction KW - physiology KW - Brain KW - Neuronal Plasticity KW - physiology. KW - Signal Transduction KW - Synapses N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Astroglia are the most abundant type of glial cells -- Their role has recently emerged as an active contributor to neural function -- The underlying mechanisms remain poorly understood -- Astrocytes release D-serine in a Ca2+ dependent manner -- Interference with this release reduces activation of synaptic NMDA receptors -- This in turn could severely impair induction of long-term synaptic potentiation -- Astroglia thus may play a fundamental role in mechanisms of memory formation in the brain; Access restricted to subscribers UR - https://hstalks.com/bs/2204/ UR - https://hstalks.com/bs/p/584/ ER -