TY - ADVS AU - Proudfoot,Amanda E.I. TI - Chemokines and their receptors: their biology and therapeutic relevance T2 - Cells of the innate immune system : roles in health and disease, PY - 2012/// CY - London PB - Henry Stewart Talks KW - Chemokines KW - Receptors KW - Effect of drugs on KW - Natural immunity KW - physiology KW - Immunity, Innate KW - Receptors, Chemokine KW - drug effects N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Chemokines are immune modulators regulating direction of cell migration -- Chemokine receptors are seven transmembrane (7TM) G protein-coupled receptors -- Chemokines need to bind to endothelial expressed proteoglycans for activity in vivo -- Excessive cell recruitment is a hallmark of inflammation -- 7TM receptors are highly druggable targets for the pharmaceutical industry -- Chemokine receptors are an essential co-receptor for HIV infectivity -- Nature uses chemokine binding proteins to iinhibit the chemokine system; Access restricted to subscribers UR - https://hstalks.com/bs/2155/ UR - https://hstalks.com/bs/p/611/ UR - https://hstalks.com/bs/p/667/ ER -