TY - ADVS AU - Soto,Claudio TI - Endoplasmic reticulum stress in neurodegenerative diseases T2 - Protein homeostasis : folding proteins and maintaining the protein-protein interaction networks, PY - 2012/// CY - London PB - Henry Stewart Talks KW - Endoplasmic reticulum KW - Nervous system KW - Degeneration. KW - Prion diseases KW - Protein folding KW - Endoplasmic Reticulum Stress KW - Neurodegenerative Diseases KW - Prion Diseases KW - Protein Folding KW - Stress, Physiological N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Neurodegenerative disease -- Misfolded aggregates deposited in the brain -- Research strategy -- Prion diseases -- Two conformations of the prion protein -- Experimental scrapie model in mice -- Upregulation of ER chaperones -- ER-stress and UPR in human CJD -- PrP interaction with ER chaperones in brain -- PrPSc induction of ER-stress and neuronal death -- Calcineurin properties -- A novel treatment for prion diseases; Access restricted to subscribers UR - https://hstalks.com/bs/2233/ UR - https://hstalks.com/bs/p/641/ ER -