TY - ADVS AU - Shamir,Ron TI - Computational methods in analysis of gene regulation and protein interactions T2 - Protein homeostasis : folding proteins and maintaining the protein-protein interaction networks, PY - 2012/// CY - London PB - Henry Stewart Talks KW - Biological models. KW - Computational biology. KW - Protein-protein interactions KW - Data processing KW - Proteomics KW - Algorithms KW - Computational Biology KW - methods KW - Gene Regulatory Networks KW - Protein Interaction Mapping KW - Systems Biology N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Finding regulatory motifs -- Finding motifs using target sets of promoters -- Problem definition -- The Amadeus motif finding algorithm -- Architecture, benchmark results and global analysis -- Finding transcriptional programs and their regulatory motifs -- Problem definition -- The Allegro software for recovering transcriptional program -- Results on yeast osmotic shock expression profiles -- Recovering microRNA binding motifs from 3' UTRs using stem cell expression profiles -- Discovering a novel motif pair in C. elegans -- Utilizing network information -- Using expression and protein interaction data -- Problem definition and the Matisse algorithm -- Demonstration of Matisse on yeast osmotic shock data -- Comparison of Matisse to other algorithms -- Demonstration of Matisse on human stem cell data -- The pluripotency network -- Using expression and protein interaction data with interaction confidence -- The Cezanne algorithm -- DNA damage response in yeast; Access restricted to subscribers UR - https://hstalks.com/bs/2219/ UR - https://hstalks.com/bs/p/641/ ER -