TY  - ADVS
AU  - Babu,M.Madan
TI  - Intrinsically unstructured proteins: regulation and disease 
T2  - Protein homeostasis : folding proteins and maintaining the protein-protein interaction networks,
PY  - 2012///
CY  - London
PB  - Henry Stewart Talks
KW  - Genetic regulation
KW  - Protein folding
KW  - Gene Expression Regulation
KW  - Protein Conformation
KW  - Protein Folding
KW  - Transcription Factors
KW  - genetics
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Regulatory genomics and systems biology -- Intrinsically unstructured proteins (IUPs): structural and biophysical advantage -- Functional advantage -- Thermodynamic and kinetic advantage -- Conformational advantage -- Identification of IUPs -- Functions of IUPs -- Disadvantages of unstructured regions -- Unstructured regions in proteins -- Cells minimize the risks of unstructured proteins -- Tight regulation of IUPs -- Key regulatory events affecting protein availability -- IUPs in yeast -- Gene-ontology functional enrichment analysis -- Genome-scale datasets on transcript availability -- Transcripts encoding IUPs are tightly controlled -- Mechanisms affecting transcript stability -- Genome-scale datasets on protein availability -- IUPs are tightly controlled at the translational level -- PEST sequences -- Aggregation prone IUPs: more tightly regulated -- Control calculation -- Tight regulation of IUPs is evolutionarily conserved -- Control of IUP affects signaling fidelity/regulation -- Control of specific IUP affects protein aggregation; Access restricted to subscribers
UR  - https://hstalks.com/bs/2216/
UR  - https://hstalks.com/bs/p/641/
ER  -