TY - ADVS AU - Wilkinson,Robert J. AU - Meintjes,Graeme TI - The role of myeloid cells in HIV associated immune reconstitution inflammatory syndrome T2 - Cells of the innate immune system : roles in health and disease, PY - 2012/// CY - London PB - Henry Stewart Talks KW - HIV Infections KW - Immunologic diseases KW - immunology KW - Immune Reconstitution Inflammatory Syndrome KW - pathology KW - Myeloid Cells KW - Tuberculosis N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: TB-immune reconstitution inflammatory syndrome (IRIS) is a common complication of combined antitubercular and antiretroviral therapy -- The two forms of IRIS: paradoxical and unmasking -- Lack of a diagnostic test for TB-IRIS -- Expansion of Interferon gamma secreting T cells is associated with TB-IRIS -- Multiple cytokines are elevated in TB-IRIS, many of myeloid origin -- Benefits of adjunctive corticosteroid therapy in TB-IRIS -- Steroid therapy reduces the levels of IL-6, IL-10, IL-12p40, TNF, Interferon-gamma and CXCL-10 in TB-IRIS patients -- Suppurative necrosis may occur in TB-IRIS, implying a role for neutrophils -- Evidence of a prominent role for myeloid cells in the pathogenesis of TB-IRIS; Access restricted to subscribers UR - https://hstalks.com/bs/2279/ UR - https://hstalks.com/bs/p/667/ ER -