TY - ADVS AU - Swanson,Michele TI - Autophagy as a barrier to infection T2 - Cells of the innate immune system : roles in health and disease, PY - 2012/// CY - London PB - Henry Stewart Talks KW - Infection KW - Immunological aspects. KW - Phagocytosis. KW - Autophagy. KW - Crohn Disease KW - immunology KW - immunology. KW - Legionella pneumophila KW - Mycobacterium tuberculosis KW - Shigella N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Autophagosome biogenesis -- Autophagy a regulated intersection of the secretory and endosomal pathways -- Genetic analysis in yeast has accelerated autophagy research -- Autophagy is inhibited by mTOR -- Autophagosome biogenesis is coordinated by a cascade of Atg proteins -- Autophagosomes mature rapidly in C57Bl/6 macrophages -- A wide variety of pathogens encounter the autophagy pathway -- Autophagy in infection and immunity -- Illustrations: Legionella pneumophila -- Shigella flexnerii -- Crohns' disease -- Mycobacterium tuberculosis -- Naip5 NOD-like receptor cytosolic surveillance protein -- Inflammasome components coordinate autophagy and pyroptosis as barriers to infection -- Autophagy enhances MHCI and MHCII antigen presentation; Access restricted to subscribers UR - https://hstalks.com/bs/2282/ UR - https://hstalks.com/bs/p/667/ ER -