TY - ADVS AU - Brown,Bob TI - Epigenetic biomarkers in cancer T2 - Biomarkers : the path forward to highly sensitive and specific molecular diagnostics, PY - 2012/// CY - London PB - Henry Stewart Talks KW - Cancer KW - Genetic aspects KW - DNA KW - Methylation KW - Epigenesis KW - Tumor markers KW - DNA Methylation KW - Epigenesis, Genetic KW - Neoplasms KW - drug therapy KW - genetics KW - Tumor Markers, Biological N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Epigenetics -- levels of control -- The patient cancer journey-multiple impact points -- Key translational areas for epigenetics -- DNA methylation as cancer biomarker -- DNA methylation analysis methods -- Epigenetic gene silencing in malignant cells -- CpG methylation and clinical outcome -- Causes of aberrant DNA methylation in cancer -- Stem cell targets -- EZH2 as a potential anti-cancer target -- Epigenetic modification as drug targets -- Epigenetic therapies -- DNA methylation versus platinum resistance -- Phase II trial of Decitabine & Carboplatin -- Effects of low doses of DNA-demethylation agents -- Epigenetic therapies challenges; Access restricted to subscribers UR - https://hstalks.com/bs/2401/ UR - https://hstalks.com/bs/p/666/ ER -