TY  - ADVS
AU  - Kingston,Robert
TI  - Maintaining the silenced state of master regulatory genes during development
T2  - Epigenetics, chromatin, transcription and cancer,
PY  - 2014///
CY  - London
PB  - Henry Stewart Talks
KW  - Chromosomal proteins
KW  - Developmental genetics
KW  - Epigenesis
KW  - Gene silencing
KW  - Genetic regulation
KW  - Drosophila Proteins
KW  - metabolism
KW  - Epigenesis, Genetic
KW  - Gene Expression Regulation, Developmental
KW  - Gene Silencing
KW  - Polycomb-Group Proteins
KW  - Repressor Proteins
KW  - Transcription Factors
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Gene repression in cell division -- Early homeotic gene expression patterns -- The polycomb group -- Mutants of polycomb fail to maintain repression -- Transcriptional memory -- Core functional PcG complexes -- Regulation of PRC2 in drosophila and humans -- PRC2 core subunits in humans -- Prominent modifications that can occur -- Chromodomains bind H3 tail marks -- Differential chromodomain binding -- Targeting of the PcG complexes -- Drosophila PREs are bound by PHO -- Mechanisms involved in targeting -- Mammalian HOX clusters are a key PRC1 target -- Human D11.12 is similar to fly PREs -- CpG islands and long non-coding RNAs -- Small RNAs specifying repression -- Noncoding RNAs influence chromatin structure -- Mode of repression -- How are genes silenced? -- PRC1 in compaction and ubiquitylation -- Nucleosome dynamics -- Characteristics of the compaction domain -- Gene silencing by chromatin compaction -- The SIR complex and mating type silencing -- Structural rearrangements in NCP and BAH -- Folding events in Sir3 BAH/NCP complex -- The nucleosome as a silencing machinery -- Epigenetic memory; Access restricted to subscribers
UR  - https://hstalks.com/bs/2742/
UR  - https://hstalks.com/bs/p/685/
ER  -