TY  - ADVS
AU  - Peters-Golden,Marc
TI  - Influence of eicosanoid lipid mediators on macrophage innate immune functions
T2  - Macrophage heterogeneity and function : role in innate and adaptive immunity,
PY  - 2014///
CY  - London
PB  - Henry Stewart Talks
KW  - Eicosanoids
KW  - Macrophages
KW  - Natural immunity
KW  - metabolism
KW  - Immunity, Innate
KW  - immunology
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Mediator paradigms in innate immunity -- Eicosanoids -- Eicosanoids in antimicrobial immunity: Yin and Yang -- The leukotriene synthetic pathway -- Role of LTB4 in bacterial killing by AMs -- Pathway for NFκB activation upon PRR ligation -- Cross-talk between PRR and GPCR pathways? -- Dectin-1 -- LTB4 enhances yeast binding via dectin-1 -- Basal dectin-1 expression depends on constitutive LTB4 generation -- LTB4 enhances dectin-1-induced cytokine generation by elicited MΦ -- Dectin-1 expression in MΦ depends on an LTB4-PU.1 axis -- Pathway for NFκB activation upon TLR ligation -- LPS-induced nuclear translocation of NFκB subunits requires endogenous LTB4/BLT1 signaling -- 5-LO metabolism is required for MyD88-dependent NFkB activity in macrophages -- 5-LO and LTB4 are required for basal MyD88 expression in macrophages -- MyD88 expression is controlled by STAT-1 and SOCS1 -- SOCS1 siRNA restores MyD88 expression and LPS responsiveness in 5-LO -/- MΦs -- PGE2 actions are context-dependent -- PGE2 synthesis and signaling -- Opposing actions of PGE2 vs. LTB4 -- Eicosanoid imbalance in states of immunosuppression; Access restricted to subscribers
UR  - https://hstalks.com/bs/2772/
UR  - https://hstalks.com/bs/p/668/
ER  -