TY  - ADVS
AU  - Wood,Nicholas
TI  - Genetic basis of neurological disease
T2  - The genetic basis of neurological disorders,
PY  - 2014///
CY  - London
PB  - Henry Stewart Talks
KW  - Nervous system
KW  - Degeneration
KW  - Genetic aspects
KW  - Diseases
KW  - Parkinson's disease
KW  - Genome-Wide Association Study
KW  - Nervous System Diseases
KW  - genetics
KW  - Neurodegenerative Diseases
KW  - Parkinson Disease
KW  - Sequence Analysis, DNA
KW  - trends
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Neurogenetics -- Allele frequency vs. effect size -- Parkinson's disease (PD) -- PINK1: genetic discovery to protein expression -- Pink1 and mitochondrial abnormalities -- In vivo interaction between PINK1 and Parkin -- Parkinsonian proteins and mitophagy -- Mitochondrial dysfunction -- Protein aggregation -- Ceramide metabolism and PD -- Lysosomal pathway and PD -- Complex trait genetics -- Linkage disequilibrium blocks -- Identifying common genetic factors -- Genetic risk factors & odds of finding variants -- First genome-wide association study for PD -- Parkinson's disease molecular pathways -- Replicate meta-analysis -- The major neurological diseases -- Caveats to consider in GWAS -- The ENCODE study -- Trinucleotide repeats and related disorders -- The impact of next generation sequencing; Access restricted to subscribers
UR  - https://hstalks.com/bs/2846/
UR  - https://hstalks.com/bs/p/908/
ER  -