TY  - ADVS
AU  - Goldberg,Alfred
TI  - Protein degradation and defense against neurodegenerative disease: part 1 of 2 
T2  - Protein homeostasis : folding proteins and maintaining the protein-protein interaction networks,
PY  - 2014///
CY  - London
PB  - Henry Stewart Talks
KW  - Brain
KW  - Aging
KW  - Molecular aspects
KW  - Nervous system
KW  - Degeneration
KW  - Protein folding
KW  - Proteins
KW  - Metabolism
KW  - Ubiquitin
KW  - Heat-Shock Proteins
KW  - Homeostasis
KW  - Lewy Bodies
KW  - Ligases
KW  - Neurodegenerative Diseases
KW  - metabolism
KW  - Proteasome Endopeptidase Complex
KW  - Protein Folding
KW  - chemistry
KW  - Proteolysis
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Neurodegenerative diseases with inclusion bodies associated with ubiquitin and proteasomes -- Abnormal proteins rapidly degraded in cells -- The ubiquitin-proteasome pathway -- Ubiquitin ligases important in neurological disease -- CHIP, Hsp70 and Hsp90 -- Conditions that induce muscle wasting -- Ubiquitin ligases in muscles atrophy -- P97/VCP -- Autophagy -- The Nedd4 ubiquitin-ligase and α-Synuclein -- The ESCRT pathway -- Proteasomal VS. lysosomal degradation (K48 and K63-linked chains) -- Expression of Nedd4 in Lewy bodies; Access restricted to subscribers
UR  - https://hstalks.com/bs/2909/
UR  - https://hstalks.com/bs/p/641/
ER  -