TY  - ADVS
AU  - Schapira,Anthony H.V.
TI  - Mitochondrial and lysosomal dysfunction in the pathogenesis of Parkinson's disease
T2  - Parkinson's disease,
PY  - 2014///
CY  - London
PB  - Henry Stewart Talks
KW  - Lysosomes
KW  - Metabolism
KW  - Mitochondrial pathology
KW  - Parkinson's disease
KW  - Pathogenesis
KW  - DNA, Mitochondrial
KW  - Gaucher Disease
KW  - metabolism
KW  - pathology
KW  - Mitochondria
KW  - Mitochondrial Degradation
KW  - Mitochondrial Diseases
KW  - Parkinson Disease
KW  - physiopathology
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Pathogenesis of Parkinson's disease (PD) -- Mitochondria (biochemistry, DNA, proteins, turnover) -- Oxidative phosphorylation and respiratory chain -- Fraction of deleted mtDNA in substantia nigra (SN) -- Mitochondrial complex I deficiency in PD -- PARK loci -- The role of mitophagy in mitochondrial turnover -- Common pathways underlying PD pathogenesis -- Ageing and PD pathogenesis -- Autosomal mitochondrial diseases -- POLG mutations -- Alpha-synuclein (SNCA) and mitochondria -- Autophagy, lysosomal dysfunction and Glucocerebrosidase (GCase) -- Gaucher disease -- Chaperone-mediated autophagy: LAMP-2A -- GBA mutations -- DAT density and disease progression in PD -- DaTScan in genetic PD -- GCase-SNCA as a target for PD -- GBA & GBA-SNCA pathway as targets for PD therapies; Access restricted to subscribers
UR  - https://hstalks.com/bs/2951/
UR  - https://hstalks.com/bs/p/805/
ER  -