TY - ADVS AU - Von Herrath,Matthias G. TI - Development of immunotherapies for type 1 diabetes: value and limitations of mouse models T2 - Animal models in biomedical research, PY - 2015/// CY - London PB - Henry Stewart Talks KW - Animal models in research KW - Diabetes KW - Animal models KW - Immunotherapy KW - Drug development KW - Mice as laboratory animals KW - Biomarkers KW - Diabetes Mellitus, Experimental KW - Diabetes Mellitus, Type 1 KW - immunology KW - Disease Models, Animal KW - Drug Discovery KW - Lymphocytic choriomeningitis virus KW - Mice, Inbred NOD KW - Models, Animal KW - Reproducibility of Results N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: The use of animal models -- Strategy T1D: a prioritization process from mice to humans -- The non-obese diabetic (NOD) mouse model: reproducibility, increasing stringency level options, predictive potential of biomarkers -- Alternate models: The RIP-LCMV mouse -- Ongoing general challenges, mitigation actions & consequences; Access restricted to subscribers UR - https://hstalks.com/bs/2991/ UR - https://hstalks.com/bs/p/916/ ER -