TY - ADVS AU - Deininger,Michael W. TI - CML: genetic paradigm of targeted therapy, part 1 of 2 T2 - Cancer genetics, PY - 2015/// CY - London PB - Henry Stewart Talks KW - Antineoplastic agents KW - Cancer KW - Genetic aspects KW - Chronic myeloid leukemia KW - Drug delivery systems KW - Protein kinases KW - Inhibitors KW - Antineoplastic Agents KW - pharmacology KW - Drug Delivery Systems KW - Fusion Proteins, bcr-abl KW - antagonists & inhibitors KW - imatinib KW - Leukemia, Myelogenous, Chronic, BCR-ABL Positive KW - drug therapy KW - genetics KW - Molecular Targeted Therapy KW - methods KW - Philadelphia Chromosome KW - drug effects KW - Protein Kinase Inhibitors KW - Protein-Tyrosine Kinases KW - Translocation, Genetic N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Typical clinical findings and phases of chronic myeloid leukaemia (CML) -- Philadelphia chromosome (juxtaposition & genomic anatomy BCR-ABL1) -- Target cells for transformation -- Molecular driver for pathogenesis (BCR-ABL1 tyrosine kinase) -- Imatinib (inhibitor of BCR-ABL1); Access restricted to subscribers UR - https://hstalks.com/bs/3131/ UR - https://hstalks.com/bs/p/941/ ER -