TY - ADVS AU - Frazier,Kendall S. TI - Antisense oligonucleotides: the promise and the problems T2 - The biomedical & life sciences collection, PY - 2015/// CY - London PB - Henry Stewart Talks KW - Antisense nucleic acids KW - Drug development KW - Toxicity testing KW - Drug Discovery KW - methods KW - Oligonucleotides, Antisense KW - adverse effects KW - therapeutic use KW - toxicity KW - Patient Safety KW - Toxicity Tests N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Antisense oligonucleotide (ASOs) therapies -- Screening strategies for drug candidates -- Locked nucleic acid (LNA) gapmers -- Understanding off-target effects (OTEs) -- Mechanisms of ASO toxicity and clinical relevance -- New targets/delivery systems under development; Access restricted to subscribers UR - https://hstalks.com/bs/3174/ ER -