TY - ADVS AU - Sim,Edith TI - Arylamine N-acetyltransferases: part 3 of 3 T2 - Drug metabolizing enzymes : fundamentals, study methods, recent advances and clinical significance, PY - 2016/// CY - London PB - Henry Stewart Talks KW - Antibacterial agents KW - Biochemical markers KW - Breast KW - Cancer KW - Drug development KW - Drugs KW - Metabolism KW - Enzyme Inhibitors KW - Isoenzymes KW - Transferases KW - Antitubercular Agents KW - Arylamine N-Acetyltransferase KW - antagonists & inhibitors KW - genetics KW - metabolism KW - Bacterial Infections KW - drug therapy KW - Biomarkers KW - Breast Neoplasms KW - diagnosis KW - Drug Discovery KW - methods KW - pharmacology KW - Ethnic Groups KW - Gene Expression Regulation, Enzymologic KW - Genetic Association Studies KW - Mice, Transgenic KW - Mycobacterium KW - drug effects KW - Pharmaceutical Preparations KW - Pharmacogenetics N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Updated version of a talk first published in 2007; Contents: Mechanism of action -- Reaction substrates -- Isoform substrate profiles -- Isoenzymes NAT1 and NAT2 -- Regulation of gene expression -- Pharmacogenetics -- Phenotype/genotype correlation -- Ethnic variation -- Transgenic mouse models -- NAT protein structures -- NAT as a biomarker in breast cancer -- NAT inhibitors as diagnostic agents -- NAT in mycobacteria -- NAT inhibitors as an approach to potential anti-tubercular agents; Access restricted to subscribers UR - https://hstalks.com/bs/3320/ UR - https://hstalks.com/bs/p/16/ ER -