TY - ADVS AU - Patel,Smita TI - DNA replication T2 - From DNA to proteins : the multiple levels of regulation, PY - 2007/// CY - London PB - Henry Stewart Talks KW - DNA replication KW - Protein-protein interactions KW - Adenosine Triphosphatases KW - Bacteriophage T7 KW - DNA Replication KW - DNA KW - chemistry KW - genetics KW - DNA-Directed DNA Polymerase KW - Proteins KW - metabolism N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Chemical composition of DNA -- Chargaff's rule -- DNA structure -- Base pairing -- Semiconservative DNA replication -- Mechanism of DNA replication -- Semi-discontinuous DNA replication -- DNA replication is catalyzed by the cooperative action of a number of proteins: what we know -- DNA polymerase structure -- Structure of phage T7 DNA polymerase -- Chemical reaction catalyzed by DNA polymerases -- Metal ions play an essential role in DNA synthesis -- DNA synthesis has to be efficient and accurate -- Rates of correct and incorrect nucleotide addition -- How are errors corrected? -- Fidelity: exonuclease activity -- Fidelity of DNA synthesis -- Processivity of the DNA polymerase -- Processivity factors -- DNA unwinding: helicase protein -- Mechanism of double helical DNA strand separation -- Mechanism of ATPase and DNA translocation -- Helicase functions in conjunction with the DNA polymerase -- Synergy between the replication proteins in catalyzing DNA replication -- Primers for DNA replication -- Properties of the DNA primase; Access restricted to subscribers UR - https://hstalks.com/bs/621/ UR - https://hstalks.com/bs/p/22/ ER -