TY - ADVS AU - Ideker,Trey TI - Protein networks and analysis of global gene expression T2 - From DNA to proteins : the multiple levels of regulation, PY - 2007/// CY - London PB - Henry Stewart Talks KW - Bioinformatics KW - Computational biology KW - Genetic regulatory networks KW - Protein protein interactions KW - Proteomics KW - Systems biology KW - Computational Biology KW - trends KW - Databases, Protein KW - Fungal Proteins KW - metabolism KW - Gene Expression Regulation KW - physiology KW - Gene Expression Regulation, Fungal KW - Gene Regulatory Networks KW - Genomics KW - methods KW - Models, Genetic KW - Protein Interaction Maps KW - genetics KW - Proteins KW - Saccharomyces cerevisiae KW - Systems Biology N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: A paradigm shift: from databases of protein sequences to protein interactions -- Technologies for measuring interactions -- Chromatin immunoprecipitation (ChIP) -- Yeast Two Hybrid (Y2H) technology -- Mass spectrometry based approaches -- Methods for querying protein networks with gene expression profiles -- Systematic validation of protein network models using gene deletions -- Cytoscape open-source software for network modeling and visualization -- Methods for network comparison across species -- Application to discover conserved protein complexes among the networks of yeast, worm, fly and Plasmodium -- Methods for querying protein networks to explain genetic (synthetic lethal) interactions -- Future directions: how network queries will enable systems biology; Access restricted to subscribers UR - https://hstalks.com/bs/639/ UR - https://hstalks.com/bs/p/22/ ER -