TY - ADVS AU - Markman,Maurie TI - Surrogate endpoints of efficacy T2 - Cancer therapy : latest thinking in efficacy and toxicity, PY - 2018/// CY - London PB - Henry Stewart Talks KW - Antineoplastic agents KW - Cancer KW - Chemotherapy KW - Treatment KW - Evaluation KW - Clinical trials KW - Outcome assessment (Medical care) KW - Antineoplastic Agents KW - administration & dosage KW - therapeutic use KW - Biomarkers KW - Clinical Trials as Topic KW - Endpoint Determination KW - Goals KW - Neoplasms KW - prevention & control KW - therapy KW - Treatment Outcome N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Updated version of a talk first published in 2009; Contents: Improvement in overall survival must be considered the single most important goal of any new antineoplastic strategy -- Also increasingly recognized that in well-defined settings it is reasonable to employ other objectively measurable endpoints of efficacy such as time to symptomatic disease progression -- The rationale for the use of surrogate or alternative endpoints in cancer clinical trials -- Examples of where such endpoints may be appropriately utilized; Access restricted to subscribers UR - https://hstalks.com/bs/1117/ UR - https://hstalks.com/bs/p/385/ ER -