TY - ADVS AU - Medina,Diego TI - Lysosome: much more than a degradative organelle T2 - Autophagy and lysosomal storage diseases, PY - 2018/// CY - London PB - Henry Stewart Talks KW - Calcium KW - Physiological effect KW - Cell death KW - Cellular signal transduction KW - Lysosomal storage diseases KW - Lysosomes KW - Autophagy KW - physiology KW - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors KW - metabolism KW - Calcium Channels KW - Cytoplasm KW - Gene Expression Regulation KW - Lysosomal Storage Diseases KW - Phosphorylation KW - Protein Transport KW - Transcription, Genetic KW - Transient Receptor Potential Channels N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Lysosome as degradative organelle -- Transcriptional regulation of lysosomal and autophagic function -- Promoting clearance through overexpression of TFEB in lysosomal storage disorders -- TFEB regulation by phosphorylation -- Imaging approaches to identify phosphatase regulating TFEB nuclear translocation -- Role of the lysosomal calcium channel TRPML1 in TFEB nuclear translocation; Access restricted to subscribers UR - https://hstalks.com/bs/3831/ UR - https://hstalks.com/bs/p/1041/ ER -