TY - ADVS AU - Masters,Seth TI - Cytoplasmic innate immune sensors T2 - Cells of the innate immune system : roles in health and disease, PY - 2019/// CY - London PB - Henry Stewart Talks KW - Cytoplasm KW - Immune system KW - Inflammation KW - Pathophysiology. KW - Natural immunity KW - Adaptive Immunity KW - Autoimmunity KW - cyclic guanosine monophosphate-adenosine monophosphate KW - immunology KW - metabolism KW - Immunity, Innate KW - Inflammasomes KW - MB21D1 protein, human KW - Nucleotides, Cyclic KW - Nucleotidyltransferases KW - Pathogen-Associated Molecular Pattern Molecules N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Introduction to the Adaptive vs. Innate Immune system -- Autoimmunity vs. Autoinflammatory disease -- Cytoplasmic innate immune sensors -- NLRs and the inflammasome -- NLRP3 inflammasome -- Pyrin inflammasome -- NLRC4 inflammasome -- NLRP1 inflammasome -- NOD1 and NOD2 -- RLRs and detection of cytoplasmic RNA/DNA -- DNA sensing by cGAS and AIM2 -- RNA sensing by Rig-I and MDA-5 -- Programmed inflammatory cell death -- Spreading the signal (cGAMP and Inflammasomes) -- PAMPs, DAMPs and HAMPs; Access restricted to subscribers UR - https://hstalks.com/bs/3804/ UR - https://hstalks.com/bs/p/667/ ER -