TY - ADVS AU - Meibohm,Bernd TI - The pharmacokinetics of therapeutic proteins T2 - The biomedical & life sciences collection, PY - 2019/// CY - London PB - Henry Stewart Talks KW - Drug development KW - Pharmaceutical biotechnology KW - Pharmacokinetics KW - Proteins KW - Therapeutic use KW - Antibodies, Monoclonal KW - Biotechnology KW - methods KW - Drug Design KW - Pharmaceutical preparations KW - metabolism KW - Pharmacology, Clinical KW - administration & dosage KW - pharmacokinetics KW - pharmacology N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Differences in the pharmacokinetics of therapeutic proteins compared to small molecule drugs -- Classes of therapeutic proteins -- Central paradigm of clinical pharmacology -- Distribution and tissue penetration of mAbs and proteins -- Three methods of renal protein metabolism -- Hepatic protein metabolism -- Target-mediated drug disposition -- Immunogenicity: general considerations and contributing factors -- Neutralizing, clearing and sustaining anti-drug antibodies; Access restricted to subscribers UR - https://hstalks.com/bs/3913/ ER -