TY - ADVS AU - Shah,Dhaval K. TI - Modeling of antibody-drug conjugate pharmacokinetics T2 - Periodic reports : advances in clinical interventions and research platforms, PY - 2019/// CY - London PB - Henry Stewart Talks KW - Antibody-drug conjugates KW - Antineoplastic agents KW - Drug development KW - Antibodies, Monoclonal KW - pharmacokinetics KW - Antineoplastic Agents KW - therapeutic use KW - Computer Simulation KW - Drug Design KW - Drug Discovery KW - methods KW - Immunoconjugates KW - pharmacology KW - Maytansine KW - Models, Biological KW - Trastuzumab N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Antibody drug conjugates (ADCs) and their uses -- Different ways to measure ADCs in the cell -- Typical ADC PK in cells -- Modeling the cellular PK of ADCs -- Modeling the tumor PK of ADCs -- 7 steps -- Modeling whole-body PK of ADCs -- Combining PK and PD models -- Kadcyla case study; Access restricted to subscribers UR - https://hstalks.com/bs/3983/ UR - https://hstalks.com/bs/p/1048/ ER -