TY  - ADVS
AU  - Ganz,Tomas
TI  - Iron metabolism and innate immunity
T2  - Innate immunity : host recognition and response in health and disease,
PY  - 2020///
CY  - London
PB  - Henry Stewart Talks
KW  - Anemia
KW  - Hemochromatosis
KW  - Iron in the body
KW  - Iron
KW  - Metabolism
KW  - Disorder
KW  - Macrophages
KW  - Natural immunity
KW  - Anemia, Iron-Deficiency
KW  - immunology
KW  - Hepcidins
KW  - Immunity, Innate
KW  - Inflammation
KW  - complications
KW  - metabolism
KW  - metal transporting protein 1
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Updated version of a talk first published in 2009; Contents: Iron is an essential element for nearly all infectious microorganisms as well as for their plant and animal hosts -- Within hours of infection, animals sequester iron within macrophages as well as in specialized extracellular proteins -- The cellular component of this response causes a marked decrease in extracellular iron concentration -- Hepcidin is a recently characterized peptide that functions as the homeostatic iron-regulatory hormone and as the mediator of inflammatory iron sequestration -- It acts by binding to the sole known cellular iron exporter, ferroportin, and inducing its internalization and degradation -- Pathological regulation or dysregulation of the hepcidin-ferroportin axis is responsible for a number of common iron-related disorders including anemia of inflammation, hereditary hemochromatosis and iron-loading anemias; Access restricted to subscribers
UR  - https://hstalks.com/bs/1304/
UR  - https://hstalks.com/bs/p/437/
ER  -