TY - ADVS AU - Messing,Albee TI - Astrocytes and Alexander disease: the first - but not last - primary astrocyte disease T2 - Physiology and pathophysiology of neuroglia : roles in health and disease, PY - 2020/// CY - London PB - Henry Stewart Talks KW - Alexander disease KW - Animal models in research KW - Astrocytes KW - Pathology KW - Nervous system KW - Degeneration KW - Alexander Disease KW - pathology KW - therapy KW - Disease Models, Animal KW - Glial Fibrillary Acidic Protein KW - metabolism KW - Mice KW - Neurodegenerative Diseases KW - Stress, Physiological N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Updated version of a talk first published in 2011; Contents: GFAP in astrocytes: isolation, genetics and function -- Alexander disease: clinical and pathologic features -- Mouse models for studying pathogenesis -- Potential therapeutic approaches: reduction of GFAP and manipulation of stress response; Access restricted to subscribers UR - https://hstalks.com/bs/2136/ UR - https://hstalks.com/bs/p/584/ ER -