TY - ADVS AU - Chernoff,Yury TI - Chaperones and prions T2 - Prions and amyloids : self-propagating protein structures in mammals, yeast and fungi, PY - 2020/// CY - London PB - Henry Stewart Talks KW - Heat shock proteins KW - Molecular chaperones KW - Prion diseases KW - Prions KW - Yeast fungi KW - Amyloid KW - Cytoskeleton KW - HSP40 Heat-Shock Proteins KW - HSP70 Heat-Shock Proteins KW - Prion Diseases KW - metabolism KW - Saccharomyces cerevisiae KW - Ubiquitin N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Updated version of a talk first published in 2008; Contents: Prion diseases -- Prions as self-propagating amyloids -- Yeast prions as protein-based heritable elements -- Prion detection -- Crucial role of the chaperone protein Hsp104 in the propagation of yeast prions -- Chaperone-mediated fragmentation turns amyloids into infectious or heritable prions -- Effects of the Hsp70 and Hsp40 proteins on yeast prions -- Other modulators of prion formation and propagation: cytoskeleton and ubiquitin system; Access restricted to subscribers UR - https://hstalks.com/bs/960/ UR - https://hstalks.com/bs/p/282/ ER -