TY  - ADVS
AU  - Lerchen,Hans-Georg
TI  - Development of antibody prodrug conjugates activated by legumain
T2  - The biomedical & life sciences collection,
PY  - 2021///
CY  - London
PB  - Henry Stewart Talks
KW  - Antibody-drug conjugates
KW  - Drug development
KW  - Antibodies, Monoclonal
KW  - Antineoplastic Agents
KW  - asparaginylendopeptidase
KW  - Cysteine Endopeptidases
KW  - Immunoconjugates
KW  - Prodrugs
KW  - TWEAK Receptor
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Modular composition of antibody drug conjugates -- ADC mode of action -- TWEAK receptor as an ADC target -- Improvements to achieve stable antibody conjugation -- KSP inhibitors as ADC toxophores -- Legumain-cleavable antibody prodrug conjugates -- Conceptualization of Antibody Prodrug Conjugates (APDCs) to increase the therapeutic window; Access restricted to subscribers
UR  - https://hstalks.com/bs/4547/
ER  -