TY - ADVS AU - Griffiths,G.M. TI - Cytotoxic T lymphocytes T2 - The immune system - key concepts and questions, PY - 2021/// CY - London PB - Henry Stewart Talks KW - Cancer KW - Immunotherapy KW - Cell-mediated cytotoxicity KW - Killer cells KW - T cells KW - Actins KW - Cytotoxicity, Immunologic KW - Fas Ligand Protein KW - Lymphohistiocytosis, Hemophagocytic KW - Neoplasms KW - therapy KW - Perforin KW - Receptors, Antigen, T-Cell KW - Receptors, Chimeric Antigen KW - T-Lymphocytes, Cytotoxic N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Cytotoxic T Lymphocytes (CTLs) -- Mechanism of action of CTLs -- CTL and the microenvironment -- Cytolytic granules -- Perforin and Fas ligand -- The role of pioneer microtubules -- Familial Haemophagocytic Lymphohistiocytosis (FHL) -- Controlling CTL killing -- The role of actin and actin depletion -- CTLs are being harnessed in immunotherapies -- Co-stimulatory signals and TCRs -- CAR-T cells; Access restricted to subscribers UR - https://hstalks.com/bs/4555/ UR - https://hstalks.com/bs/p/1067/ ER -