TY  - ADVS
AU  - Hutton,Michael
TI  - The role of MAPT (Tau) in neurodegenerative disease: one bullet with many triggers 
T2  - Neurodegenerative diseases : fundamentals, research methods, latest advances,
PY  - 2022///
CY  - London
PB  - Henry Stewart Talks
KW  - Alzheimer's disease
KW  - Frontotemporal dementia
KW  - Nervous system
KW  - Degeneration
KW  - Diseases
KW  - Proteins
KW  - Pathophysiology
KW  - tau Proteins
KW  - adverse effects
KW  - genetics
KW  - Alzheimer Disease
KW  - Brain
KW  - pathology
KW  - Corticobasal Degeneration
KW  - Frontotemporal Dementia
KW  - Haplotypes
KW  - Mice,Transgenic
KW  - Neurodegenerative Diseases
KW  - metabolism
KW  - Neurofibrillary Tangles
KW  - Supranuclear Palsy, Progressive
KW  - Tauopathies
KW  - therapy
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Updated version of a talk first published in 2007; Contents: Medical importance of tauopathies -- Microtubule Associated Protein Tau (MAPT) is incorporated into neurofibrillary lesions -- Mutations in the MAPT gene give rise to Frontotemporal dementia with parkinsonism (FTDP-17) -- Common variability in the MAPT, the so-called H1/H1 haplotype and sporadic tauopathies -- Progressive supranuclear Palsy and Cortico-basal degeneration -- Constitutive and conditional transgenic mouse models of tauopathy -- The JNPL3 mouse model of tauopathy -- Neurofibrillary tau pathology in the JNPL3 mice -- A-beta and MAPT pathologies can interact during the development of Alzheimer's disease -- Conditional rTg4510 model of tauopathy -- Major mechanism of neurodegeneration in tauopathy -- Potential therapeutic applications; Access restricted to subscribers
UR  - https://hstalks.com/bs/227/
UR  - https://hstalks.com/bs/p/31/
ER  -