The pRB/E2F pathway [electronic resource] / Jacqueline Lees.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Cell division cycle : controlling when and where cells divide and differentiate: Publisher: London : Henry Stewart Talks, 2009Description: 1 online resource (1 streaming video file (33 min.) : color, sound)Subject(s): Cell Cycle ProteinsOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: The E2F transcription factors control cell cycle entry -- The pRB/E2F pathway -- pRB and E2F are both families of proteins -- Differential roles of the pocket proteins -- Repression and activation of E2F target genes is regulated by distinct E2F complexes -- Rb mutant mice -- Inhibition of the activating E2Fs is key to pRB's tumor suppressive activity -- The activating E2Fs can also induce apoptosis and senescence genes in tumor cells -- Role of pRB-E2F in DNA damage response -- pRB contributes to the activation of pro-apoptotic genes in response to DNA damage.
Access restricted to subscribers.
Mode of access: World Wide Web.