The spindle checkpoint [electronic resource] / Kevin G. Hardwick.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Cell division cycle : controlling when and where cells divide and differentiate: Publisher: London : Henry Stewart Talks, 2009Description: 1 online resource (1 streaming video file (54 min.) : color, sound)Subject(s): Cell Cycle | MitosisOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Cell cycle checkpoints -- The metaphase to anaphase transition -- The spindle checkpoint -- What do cells monitor? -- Unattached kinetochores -- Lack of tension -- Checkpoint components -- Budding yeast genetic screens -- Microcolony assay -- Localisation of Mad proteins -- Checkpoint proteins are all recruited kinetochores -- Role of kinetochores -- Global signaling -- Identification of Cdc20 as the checkpoint effector -- CdC20-APC -- FRAP -- Mad1/Mad2 complex as a template -- The anaphase promoting complex (APC) -- How is anaphase onset inhibited -- Mad2 and Mad3 bind mitotic APC -- Separase regulation by securin -- Error correction -- Chromosomal passenger proteins -- How to sense a lack of tension? -- Checkpoint role(s) of Aurora kinase (Ipl1) -- Checkpoint silencing -- Disease relevance -- Future directions.
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Mode of access: World Wide Web.