Role and regulation of Cdk inhibitors in development and cancer [electronic resource] / Martine F. Roussel.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Cell division cycle : controlling when and where cells divide and differentiate: Publisher: London : Henry Stewart Talks, 2009Description: 1 online resource (1 streaming video file (30 min.) : color, sound)Subject(s): Cell Cycle | Cyclin-Dependent Kinase Inhibitor ProteinsOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Somatic cell cycle -- Rb pathway -- Positive regulation of G1 phase by phosphorylation of the retinoblastoma protein (Rb) by cyclin-dependent kinases (Cdks) -- Negative regulation of G1 by Cdk-inhibitory proteins (CKIs) -- Rb pathway is often disrupted in cancers -- Two families of CKIs, differential expression in embryogenesis and adult mouse tissues -- Loss of p18Ink4c and p19ink4d induces male sterility -- Loss of p19Ink4d induces progressive deafness after birth -- Loss of p19Ink4d and p27Kip1 induces re-entry of differentiated postmitotic neurons in cycle after birth -- Loss of Ink4c and Patched or p53 induces medulloblastoma, a pediatric tumor of the cerebellum -- CKIs are required for exit from and maintenance of cell cycle exit, or quiescence, a reversible state -- Loss of CKIs leads to sterility, deafness and cancers.
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Mode of access: World Wide Web.