Regulation of mammalian cell division by the chromosomal passenger complex [electronic resource] / Susanne M. A. Lens.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Cell division cycle : controlling when and where cells divide and differentiate: Publisher: London : Henry Stewart Talks, 2009Description: 1 online resource (1 streaming video file (43 min.) : color, sound)Subject(s): Cell Cycle | Genes, cdcOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Cell division -- Cancer and chromosomal instability -- Cell division errors and aneuploidy -- The chromosomal passenger complex (CPC) -- The CPC executes various functions in the dividing cell -- Regulation of Aurora B kinase activity and localization -- Centromeres and kinetochores -- Perturbation of the CPC results in severe chromosome congression and segregation defects -- Requirements for faithful chromosome segregation -- The CPC promotes bi-orientation by influencing kinetochore-microtubule interactions -- CPC substrates at the kinetochore -- Hec1/Ndc80 -- The CPC is essential for a functional mitotic checkpoint -- The dynamic localization at centromeres -- Transfer to the central spindle -- The CPC and cytokinesis -- Aurora kinase inhibitors as anti-cancer drugs.
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Mode of access: World Wide Web.