Replication licensing [electronic resource] / J. Julian Blow.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Cell division cycle : controlling when and where cells divide and differentiate: Publisher: London : Henry Stewart Talks, 2009Description: 1 online resource (1 streaming video file (47 min.) : color, sound)Subject(s): Cell Cycle | Genes, cdc | Licensure, MedicalOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Problems in ensuring complete genome replication -- Experiments revealing the existence of a replication licence -- The licensing reaction -- ORC, Cdc6, Cdt1 and Mcm2-7 -- Cell cycle regulation of licensing -- Pre-RC substrates in yeast -- Regulation of licensing in animal cells by Cdt1 degradation and geminin inhibition -- Is there a licensing checkpoint? -- Replication licensing and cancer -- The "MCM paradox" and dormant replication origins -- The licensing system as a potential anti-cancer target.
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Mode of access: World Wide Web.