From bench to bedside [electronic resource] : evolution of anti-TNFα therapy in rheumatoid arthritis / Ravinder Maini.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Innate immunity : host recognition and response in health and disease: Publisher: London : Henry Stewart Talks, 2009Description: 1 online resource (1 streaming video file (59 min.) : color, sound)Subject(s): Arthritis, Rheumatoid -- drug therapy | Immunity, Innate | Tumor Necrosis Factor-alphaOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: What are cytokines? -- Early experiments -- Human cytokines in the 1980s -- Identification of TNFalfa at protein and genomic level -- TNFalfa and anti- TNFalfa antibodies -- Rheumatoid arthritis (RA): burden of disease -- Pathology of RA -- IL-1 and TNFalfa -- Cytokine cascade in RA -- A molecular hypothesis -- First anti-TNF (cA2/infliximab) in clinical trials in RA -- How does anti-TNF work? -- Why is cellularity reduced? -- Anti-TNF therapy inhibits cartilage and especially bone destruction -- Infliximab regulates altered T and B cell immunity -- Biological effects of Infliximab -- Anti-TNF biologicals in the lab -- Efficacy in randomized clinical trials -- Effective anti-TNF therapy demonstrates shared TNF-pathways in other diseases -- Adverse events and safety issues -- Limitations of anti-TNF therapy -- After TNF: what are we looking for?
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Mode of access: World Wide Web.