Innate immune sensing and response [electronic resource] / Bruce Beutler.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Innate immunity : host recognition and response in health and disease: Publisher: London : Henry Stewart Talks, 2009Description: 1 online resource (1 streaming video file (62 min.) : color, sound)Subject(s): Immunity, InnateOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Sensing infection is essential to the initiation of an immune response -- The innate immune system senses signature molecules made by microbes using a conserved set of germline-encoded receptors -- This receptor family (the Toll-like receptors) was first understood when a mutation that abolished lipopolysaccharide (LPS) sensing was positionally cloned in mice -- In Drosophila a homologous receptor is also used to detect infection, and still another receptor activates a pathway evocative of the tumor necrosis factor (TNF) pathway in mammals -- Further work in mammals has depended upon gene targeting and also forward genetic work, which has revealed many of the components of the TLR signaling apparatus -- Forward genetics has also allowed us to see how many genes (and what kinds of genes) are important for resisting an infection in vivo.
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Mode of access: World Wide Web.