Predicting TSE transmission [electronic resource] / Jean Manson.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Prions and amyloids : self-propagating protein structures in mammals, yeast and fungi: Publisher: London : Henry Stewart Talks, 2008Description: 1 online resource (1 streaming video file (41 min.) : color, sound)Subject(s): Amyloid | PrionsOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: The TSEs continue to pose a problem to animal and human health -- The vCJD epidemic appears to be in decline but new risks of human to human transmission are now apparent -- Chronic wasting disease is a major problem currently in the US although its presence has not yet been detected in Europe -- Predicting and preventing transmission of disease requires an understanding of the routes of transmission within and between animals and the host factors which determine susceptibility -- We have studied natural disease and both in vivo and in vitro model systems to unravel the basic mechanisms of disease -- PrP protein has a central role in the outcome disease and mutations and polymorphisms in host PrP can profoundly alter the host's susceptibility to a TSE agent -- Precisely how host PrP influences the outcome of disease has not been established -- Both mutations and glycosylation can profoundly influence transmission both within and between species.
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Mode of access: World Wide Web.