Admixture mapping [electronic resource] / Paul McKeigue.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Genetic epidemiology II : latest developments: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (40 min.) : color, sound)Subject(s): Genetic Predisposition to Disease -- epidemiologyOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Applications of statistical modelling of population admixture -- Genetic and environmental explanations for ethnic differences in disease risk -- Methods for finding genes that influence complex traits -- Exploiting admixture to map genes -- Statistical power of admixture mapping -- Advantages of admixture mapping in comparison with other approaches to finding disease susceptibility genes -- Methodological problems of extending linkage analysis of a cross to admixed human populations -- Statistical methods that allow linkage analysis of a cross to be extended to admixed humans -- Model for stochastic variation of ancestry on chromosomes inherited from an admixed parent -- Multipoint inference of ancestry at marker loci from genotypes -- Null hypothesis as graphical model -- Statistical approach to model fitting and hypothesis testing -- The score test algorithm -- Other model diagnostics: "Bayesian p-values" -- How many markers are required for genome-wide admixture mapping? -- Panels of ancestry-informative markers -- Other applications of statistical modelling of admixture.
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Mode of access: World Wide Web.